Facility

Genzyme Pharmaceuticals production facility is located in Liestal, Switzerland, approximately 15 kilometers from Basel. Our 80,000 square foot, expandable, facility includes research, scale-up, process development and quality control laboratories as well as chemical manufacturing installations. Our multi-purpose reactor units and manufacturing capabilities are described below:

Multi Purpose Synthesis Plant
Reaction volumes up to 2,500 liters

Contracted access to additional capacity

Classified Clean Rooms
Class 100,000 and 10,000 clean rooms

Class 100 laminar flow cabinets for product handling and filtration

Peptide Synthesis
Fmoc solid phase synthesis up to 150 liters
Batches of crude peptides (prior to HPLC purification & lyophilization) and peptide segments up to multi-kilogram batches
Multi-100 kilogram annual production capacity

Solution-phase synthesis up to 2,500 liters
Batches of short peptides or peptide segments (typically in the range 2-5 amino acid residues) up to approximately 100 kilograms
Multi-ton annual production capacity

Segment Condensation
Batches of crude peptide (prior to HPLC purification & lyophilization) up to multi-kilogram

Amino Acid Derivative Production
Up to 100 kilogram batches

Phospholipid Production
Up to 50 kilogram batches

HPLC Purification
Numerous preparative HPLC columns available

Lyophilization
Dedicated Class 10,000 clean room
Batches up to multi-kilogram

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