Facility and Infrastructure

As a business unit of Genzyme Corporation, Genzyme Pharmaceuticals’ corporate infrastructure allows for the autonomy of a distinct business within one of the world’s leading biotechnology companies. We pride ourselves on integrating this resource with skilled people, a strong foundation in chemistry, and a state-of-the-art facility to meet the highest standards of quality for your custom manufacturing needs.

Genzyme Pharmaceuticals’ cGMP manufacturing facility is located in Liestal, Switzerland, just 15 kilometers from Basel, and less than 80 from Zurich. Production capabilities range from small kilo to ton capacity, providing optimized value, cost considerations, and supply chain management for each customer’s position in the commercialization process. Custom manufactured products include registered intermediates, APIs, specialty chemicals, and materials used as liposomes and solid lipid nanoparticles in delivering the active drug substance itself.

The following flexible and adaptable equipment is currently utilized in our 100,000 square foot Liestal facility:

General Manufacturing

For reactions between -100°C and +160°C:

From 60 to 2,500 liters

From 25 to 160 liters in a Class 100,000 (ISO class 8) clean room

For reactions up to 25 bar pressure:

1,000 liter glass-lined hydrogenators

Hastelloy hydrogenators

For reactions between -100°C and +250°C:

Larger volumes available through manufacturing partner

Solid-Phase Peptide Synthesis

Up to 1,000 liter volume

Chromatography

200 to 300 liter flash chromatography column (glass)

Classified Clean Rooms

Class 100,000 (ISO class 8) and 10,000 (ISO class 7) clean rooms
Class 100 (ISO class 5) laminar air flow cabinets

Lyophilization

Lyophilizer for up to 25 kg of purified peptide solution in a Class 10,000 (ISO class 7) clean room
Various vacuum lyophilizers (for intermediates only) in a Class 100,000 (ISO class 8) clean room and in controlled rooms

Other Dryers in a Class 100,000 (ISO Class 8) clean room

Up to 1,000 liter stainless steel or enamel-coated vacuum dryer
Up to 1,000 liter plate, cone, stirring, filter dryers

HPLC Purification (closed handling) in a dedicated room

Preparative HPLC columns of various sizes available
Up to 90cm (ht.) x 15cm (dia.)