Lipids

Synthetic lipids offer exciting opportunities for drug delivery with unique pharmaceutical benefits. One example is liposomal drug delivery, where self-assembled liposome vesicles target drugs to selective tissues. Lipids can increase efficacy and therapeutic index while improving the pharmacokinetics and solubility of an associated drug. Cell transfection for oligonucleotide delivery (e.g. siRNA, miRNA) and solid lipid particles for pulmonary delivery are other examples of enhanced drug delivery.

Whether used as an Active Pharmaceutical Ingredient or critical formulation excipient of a lipid delivery system, Corden Pharma’s comprehensive range of synthetic phospholipids, sphingolipids, cationic lipids, "helper" lipids, and other lipid analogues offers an excellent choice for your drug product development and manufacturing needs. Our extensive experience in lipids allows for development and production of lipid analogues based on customer demand.

Synthetically produced lipids have the same structure as their semisynthetic counterparts or those extracted from natural sources, but offer significant advantage to the formulation scientist. Corden Pharmas’ synthetic phospholipids are single compounds of high purity produced with an efficient manufacturing process allowing the production of large batches with guaranteed bath-to-batch consistency. They carry no risk of contamination from undetected biological impurities which occur in natural lecithin starting material and all starting materials are fully characterized. Our phospholipids are generally purified by crystallization; they can be systematically analyzed for all theoretical impurities and degradation products.

Corden Pharma’s expertise in lipid chemistry has been widely used by customers seeking development and manufacture of a novel lipid or lipid conjugate for pharmaceutical use. Customers also take advantage of our custom peptide manufacturing skill to produce peptide conjugates (lipo-peptides).

We look forward to the opportunity to discuss these capabilities relative to your particular project needs.