Discovery

Pharmaceutical and biotechnology companies involved in peptide discovery can benefit from the capabilities and competencies of Genzyme Pharmaceuticals and our strategic relationships.

Libraries for Lead Optimization

The Mimotopes-Genzyme Pharmaceuticals alliance Supplies Every Link in the Peptide Chain from hit-finding to GMP production and formulation development. Mimotopes Pty Ltd of Australia specializes in designing and producing peptide libraries for candidate selection. Once a hit has been identified, Mimotopes offers the synthesis of focused follow-up libraries for hit confirmation and lead optimization from milligram to gram quantities.

Optimization for Formulation

During peptide discovery, consideration of formulation is often overlooked. Design for Peptide Delivery^SM is a concept developed by the Brookwood - Genzyme Pharmaceuticals Collaboration. This service renders active substances more suitable for formulation and sustained drug delivery for companies working in discovery and early stage development. This may be done by modifying the chemical and/or physical properties of the peptide Active Pharmaceutical Ingredient (API) as well as adapting the delivery system to achieve the desired release profile for the drug.

Central Nervous System (CNS) Pharmacokinetics

Genzyme Pharmaceuticals and Pharmidex Limited have developed Cerense^SM, which is the world’s first integrated solution to release the value of your CNS portfolio by unlocking the blood-brain barrier and measuring brain penetration. This is achieved through the combination of Genzyme Pharmaceuticals’ patented LipoBridge^®  CNS drug delivery technology and the unique expertise of Pharmidex to determine neuropharmacokinetics.

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